UNIPR

The Biochemistry Laboratory at the University of Parma applies biochemical/biophysical and molecular techniques to the study of protein function, the kinetics and dynamics of enzymes and protein complexes. The group has an excellent research record in Hb characterization, enzymology and the study of protein-protein interactions.
Within the ERASE project (PRIN2020 – Prot. 2020AE3LTA), the group is involved in the production of the proteins of interest, the characterization of their structure, function and activity and the evaluation of their potential interactions with other proteins or ligands. The group is also involved in the set up of an in vitro screening platform to analyse molecules with potential antimicrobial activity.

Prof. Stefano Bettati

Stefano Bettati is full professor of Applied Physics at the Department of Medicine and Surgery of the University of Parma.
He is a biophysicist with main research focus on protein structure and dynamics.
He is the National coordinator of the ERASE Project.

Scopus: https://www.scopus.com/authid/detail.uri?authorId=6701826075
ORCID: https://orcid.org/my-orcid?orcid=0000-0001-6787-0594
Email: stefano.bettati@unipr.it

Prof. Barbara Campanini

Barbara Campanini is associate professor of Biochemistry at the Department of Food and Drug, University of Parma.
She is interested in the biochemistry of amino acids metabolism, especially cysteine metabolism in bacteria and D-serine metabolism in mammalian CNS. Recently her interest has focused on the exploitation of cysteine biosynthetic enzymes as potential targets for antibiotics and/or enhancers of antibiotic therapy, on the functional characterization of pathogenic variants of the enzymes of the phosphorylated pathway of serine biosynthesis and on molecular mechanisms of iron acquisition by Staphylococcus aureus.

Scopus: https://www.scopus.com/authid/detail.uri?authorId=6603049902
ORCID: https://orcid.org/0000-0003-0359-0627
Email: barbara.campanini@unipr.it

Prof. Luca Ronda

Luca Ronda is associated professor of Applied Physics at the Department of Medicine and Surgery of the University of Parma.
His research is focused on structural and functional characterization of proteins, in particular on hemoglobins, through spectroscopic techniques. He also worked at the development and characterization of hemoglobin-based oxygen carriers.

Scopus: https://www.scopus.com/authid/detail.uri?authorId=6602948271
ORCID: https://orcid.org/0000-0002-5389-2669
Email: luca.ronda@unipr.it

Prof. Serena Faggiano

Serena Faggiano is associate professor of Biochemistry at the Department of Food and Drug of the University of Parma.
Her research focuses on the characterization of the structure, function and dynamic of proteins of pharmaceutical interest.

Scopus: https://www.scopus.com/authid/detail.uri?authorId=15131234800
ORCID: https://orcid.org/0000-0002-7447-9945
Email: serena.faggiano@unipr.it

Dott. Marialaura Marchetti

Marialaura Marchetti is an Assistant Professor in Applied Physics at the Department of Medicine and Surgery of the University of Parma, and she is part of Prof. Stefano Bettati’s group. She is interested in the study of the structural properties and conformational dynamics of virulence-associated bacterial proteins as putative targets to develop new antimicrobials.

Scopus: https://www.scopus.com/authid/detail.uri?authorId=55861816000
ORCID: https://orcid.org/0000-0002-4615-6786
Email: marialaura.marchetti@unipr.it

Dott. Omar De Bei

Omar De Bei is a postdoctoral fellow. He obtained his PhD from the Department of Food and Drug, University of Parma where he worked on the characterization of the interaction between the Staphylococcus aureus hemophore IsdB and human hemoglobin as a novel antimicrobial target. He acquired a solid background in biochemical and biophysical techniques during his MSc thesis and early PhD, then he started a formative path toward structural biology during his PhD secondments. His project involves applying cryo-EM single particle analysis to further investigate the molecular mechanism of iron acquisition by S. aureus.

Scopus: https://www.scopus.com/authid/detail.uri?authorId=57194065422
ORCID: https://orcid.org/0000-0003-3916-8858
Email: omar.debei@unipr.it

Dott. Francesco Marchesani

Francesco Marchesani (FM) is a Post-Doc researcher at the Laboratory of Biochemistry and Molecular Biology of the University of Parma. He is graduated in Pharmaceutical Chemisitry and Technology and has a PhD in ‘’Drugs, Biomolecules and Health Products’’. His main experties are related to enzymology and the evaluation of structure/function relationship of proteins of pharmaceutical interest. During his career, FM has mainly worked on projects concerning the study of enzymes involved in the metabolism of serine in the central nervous system . His actual project is related to the biochemical and biophysical characterisation of proteins involved in the iron assimilation by Staphylococcus aureus and the discovery of new molecular entities showing antimicrobial activity.

Scopus: https://www.scopus.com/authid/detail.uri?authorId=56845354800
ORCID: https://orcid.org/0000-0003-4384-9015
Email: francesco.marchesani@unipr.it

Monica Cozzi

Monica Cozzi is a PhD student at the University of Parma. She’s graduated with a Master degree in Molecular and Medical Biotechnology at the University of Verona, presenting an experimental thesis entitled “Development of a CRISPR/Cas9 miR-knockout cell model to study the miR-34a role in NF-κB pathway activation”. Her PhD project focuses on the study and characterization of proteins involved in the pathway of iron assimilation by S. aureus and their targeting for the development of new molecules with antimicrobial activity or adjuvants of antimicrobial therapy.

Email: monica.cozzi@unipr.it

Valeria Buoli Comani

Valeria Buoli Comani is a PhD student in Drug Sciences at the University of Parma, under the supervisor of Prof. Serena Faggiano. She is graduated in Pharmaceutical Chemisitry and Technology. Her Master’s thesis was focused on the functional characterization of phosphoserine phosphatase, an enzyme involved in the biosinthesis of L-serine in the brain, and its variants. The aim of her PhD project the comprehension of the mechanism of hemophore-mediated iron acquisition by Staphylococcus aureus and the study of inhibitors able to interfere with this target.

Email: valeria.buolicomani@unipr.it